Oxidative stress and myocardial gene alterations associated with doxorubicin-induced cardiotoxicity in rats persist for two months after treatment cessation
نویسندگان
چکیده
Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Expérimentales, EA 2979, IFR Santé-STIC, Facultés de Médecine et Pharmacie, 7 bd Jeanne d’Arc, 21000 Dijon, France (C.R., S.D.C., J.C.J, M.Z., Y.C., L.R., C.V.); Department of Pharmacology, Physiology and Physiopathology; Faculty of Pharmacy, University of Medicine and Pharmacy, Cluj-Napoca, Romania (S.G.); Département de nutrition et Institut de Cardiologie de Montréal, Université de Montréal, Québec, Canada (C.D.R.). JPET Fast Forward. Published on September 20, 2011 as DOI:10.1124/jpet.111.185892
منابع مشابه
Oxidative stress and myocardial gene alterations associated with Doxorubicin-induced cardiotoxicity in rats persist for 2 months after treatment cessation.
The molecular mechanisms underlying doxorubicin (DOX)-induced cardiomyopathy include alterations in cardiomyocytes' oxidative stress status and in gene expression. Although such alterations have been reported during in vivo DOX treatment of animals, it remains to be clarified whether they persist after treatment cessation. To address this question, rats were injected with either saline (1 ml/kg...
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